Questões de Concurso Público UNICAMP 2024 para Profissional de Pesquisa, Engenharia e Tecnologia
Foram encontradas 10 questões
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263838
Inglês
Texto associado
Leia o texto para responder à questão.
Cell culture experiments are widely used in biomedical
research, regenerative medicine, and biotechnological
production. Due to restrictions on the use of laboratory animals
by animal protection laws and the strict implementation of the
3Rs (Replacement, Reduction, and Refinement) formulated
by William Russell and Rex Burch to improve the welfare
of animals, it can be expected that the general use of cell
lines will further increase during the next years to substitute
animal-based research. However, it should be noted that cell
culture experiments, if not properly conducted, are prone to
errors. Therefore, it is essential that cell culture studies are
performed with good cell culture practice (GCCP) to assure
the reproducibility of in vitro experimentation.
In particular, inter- and intra-specific cross-contamination
and cell misidentification, genetic drift, contamination with
bacteria, fungi, yeast, viruses, or chemicals, and lack of quality
control testing are widespread fatal cell culture problems that
contaminate the literature with false and irreproducible results.
Rough estimates suggest that the number of published papers
that used problematic cell lines is about 16.1%. Moreover, the
International Cell Line Authentication Committee (ICLAC) lists
576 misidentified or cross-contaminated cell lines in its latest
register released in June 2021.
(Weiskirchen S, Schröder SK, Buhl EM, Weiskirchen R. A Beginner’s
Guide to Cell Culture: Practical Advice for Preventing Needless Problems.
Cells. 2023 Feb 21;12(5):682. doi: 10.3390/cells12050682.
PMID: 36899818; PMCID: PMC10000895.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10000895/. Adaptado)
The text is mainly about
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263839
Inglês
Texto associado
Leia o texto para responder à questão.
Cell culture experiments are widely used in biomedical
research, regenerative medicine, and biotechnological
production. Due to restrictions on the use of laboratory animals
by animal protection laws and the strict implementation of the
3Rs (Replacement, Reduction, and Refinement) formulated
by William Russell and Rex Burch to improve the welfare
of animals, it can be expected that the general use of cell
lines will further increase during the next years to substitute
animal-based research. However, it should be noted that cell
culture experiments, if not properly conducted, are prone to
errors. Therefore, it is essential that cell culture studies are
performed with good cell culture practice (GCCP) to assure
the reproducibility of in vitro experimentation.
In particular, inter- and intra-specific cross-contamination
and cell misidentification, genetic drift, contamination with
bacteria, fungi, yeast, viruses, or chemicals, and lack of quality
control testing are widespread fatal cell culture problems that
contaminate the literature with false and irreproducible results.
Rough estimates suggest that the number of published papers
that used problematic cell lines is about 16.1%. Moreover, the
International Cell Line Authentication Committee (ICLAC) lists
576 misidentified or cross-contaminated cell lines in its latest
register released in June 2021.
(Weiskirchen S, Schröder SK, Buhl EM, Weiskirchen R. A Beginner’s
Guide to Cell Culture: Practical Advice for Preventing Needless Problems.
Cells. 2023 Feb 21;12(5):682. doi: 10.3390/cells12050682.
PMID: 36899818; PMCID: PMC10000895.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10000895/. Adaptado)
According to what is stated in the first paragraph, William
Russel and Rex Burch aimed at improving
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263840
Inglês
Texto associado
Leia o texto para responder à questão.
Cell culture experiments are widely used in biomedical
research, regenerative medicine, and biotechnological
production. Due to restrictions on the use of laboratory animals
by animal protection laws and the strict implementation of the
3Rs (Replacement, Reduction, and Refinement) formulated
by William Russell and Rex Burch to improve the welfare
of animals, it can be expected that the general use of cell
lines will further increase during the next years to substitute
animal-based research. However, it should be noted that cell
culture experiments, if not properly conducted, are prone to
errors. Therefore, it is essential that cell culture studies are
performed with good cell culture practice (GCCP) to assure
the reproducibility of in vitro experimentation.
In particular, inter- and intra-specific cross-contamination
and cell misidentification, genetic drift, contamination with
bacteria, fungi, yeast, viruses, or chemicals, and lack of quality
control testing are widespread fatal cell culture problems that
contaminate the literature with false and irreproducible results.
Rough estimates suggest that the number of published papers
that used problematic cell lines is about 16.1%. Moreover, the
International Cell Line Authentication Committee (ICLAC) lists
576 misidentified or cross-contaminated cell lines in its latest
register released in June 2021.
(Weiskirchen S, Schröder SK, Buhl EM, Weiskirchen R. A Beginner’s
Guide to Cell Culture: Practical Advice for Preventing Needless Problems.
Cells. 2023 Feb 21;12(5):682. doi: 10.3390/cells12050682.
PMID: 36899818; PMCID: PMC10000895.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10000895/. Adaptado)
No trecho do primeiro parágrafo – Due to restrictions on
the use of laboratory animals – a expressão em negrito
introduz uma
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263841
Inglês
Texto associado
Leia o texto para responder à questão.
Cell culture experiments are widely used in biomedical
research, regenerative medicine, and biotechnological
production. Due to restrictions on the use of laboratory animals
by animal protection laws and the strict implementation of the
3Rs (Replacement, Reduction, and Refinement) formulated
by William Russell and Rex Burch to improve the welfare
of animals, it can be expected that the general use of cell
lines will further increase during the next years to substitute
animal-based research. However, it should be noted that cell
culture experiments, if not properly conducted, are prone to
errors. Therefore, it is essential that cell culture studies are
performed with good cell culture practice (GCCP) to assure
the reproducibility of in vitro experimentation.
In particular, inter- and intra-specific cross-contamination
and cell misidentification, genetic drift, contamination with
bacteria, fungi, yeast, viruses, or chemicals, and lack of quality
control testing are widespread fatal cell culture problems that
contaminate the literature with false and irreproducible results.
Rough estimates suggest that the number of published papers
that used problematic cell lines is about 16.1%. Moreover, the
International Cell Line Authentication Committee (ICLAC) lists
576 misidentified or cross-contaminated cell lines in its latest
register released in June 2021.
(Weiskirchen S, Schröder SK, Buhl EM, Weiskirchen R. A Beginner’s
Guide to Cell Culture: Practical Advice for Preventing Needless Problems.
Cells. 2023 Feb 21;12(5):682. doi: 10.3390/cells12050682.
PMID: 36899818; PMCID: PMC10000895.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10000895/. Adaptado)
No trecho do primeiro parágrafo – However, it should be
noted that cell culture experiments – o termo em negrito
pode ser substituído, sem alteração de sentido, por
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263842
Inglês
Texto associado
Leia o texto para responder à questão.
Cell culture experiments are widely used in biomedical
research, regenerative medicine, and biotechnological
production. Due to restrictions on the use of laboratory animals
by animal protection laws and the strict implementation of the
3Rs (Replacement, Reduction, and Refinement) formulated
by William Russell and Rex Burch to improve the welfare
of animals, it can be expected that the general use of cell
lines will further increase during the next years to substitute
animal-based research. However, it should be noted that cell
culture experiments, if not properly conducted, are prone to
errors. Therefore, it is essential that cell culture studies are
performed with good cell culture practice (GCCP) to assure
the reproducibility of in vitro experimentation.
In particular, inter- and intra-specific cross-contamination
and cell misidentification, genetic drift, contamination with
bacteria, fungi, yeast, viruses, or chemicals, and lack of quality
control testing are widespread fatal cell culture problems that
contaminate the literature with false and irreproducible results.
Rough estimates suggest that the number of published papers
that used problematic cell lines is about 16.1%. Moreover, the
International Cell Line Authentication Committee (ICLAC) lists
576 misidentified or cross-contaminated cell lines in its latest
register released in June 2021.
(Weiskirchen S, Schröder SK, Buhl EM, Weiskirchen R. A Beginner’s
Guide to Cell Culture: Practical Advice for Preventing Needless Problems.
Cells. 2023 Feb 21;12(5):682. doi: 10.3390/cells12050682.
PMID: 36899818; PMCID: PMC10000895.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10000895/. Adaptado)
O trecho em negrito do primeiro parágrafo – cell culture
experiments, if not properly conducted, are prone to
errors – apresenta, no contexto, uma
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263843
Inglês
Texto associado
Leia o texto para responder à questão.
Cell culture experiments are widely used in biomedical
research, regenerative medicine, and biotechnological
production. Due to restrictions on the use of laboratory animals
by animal protection laws and the strict implementation of the
3Rs (Replacement, Reduction, and Refinement) formulated
by William Russell and Rex Burch to improve the welfare
of animals, it can be expected that the general use of cell
lines will further increase during the next years to substitute
animal-based research. However, it should be noted that cell
culture experiments, if not properly conducted, are prone to
errors. Therefore, it is essential that cell culture studies are
performed with good cell culture practice (GCCP) to assure
the reproducibility of in vitro experimentation.
In particular, inter- and intra-specific cross-contamination
and cell misidentification, genetic drift, contamination with
bacteria, fungi, yeast, viruses, or chemicals, and lack of quality
control testing are widespread fatal cell culture problems that
contaminate the literature with false and irreproducible results.
Rough estimates suggest that the number of published papers
that used problematic cell lines is about 16.1%. Moreover, the
International Cell Line Authentication Committee (ICLAC) lists
576 misidentified or cross-contaminated cell lines in its latest
register released in June 2021.
(Weiskirchen S, Schröder SK, Buhl EM, Weiskirchen R. A Beginner’s
Guide to Cell Culture: Practical Advice for Preventing Needless Problems.
Cells. 2023 Feb 21;12(5):682. doi: 10.3390/cells12050682.
PMID: 36899818; PMCID: PMC10000895.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10000895/. Adaptado)
According to the second paragraph, an example of
contaminant that may be present during in vitro cell
culture is:
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263844
Inglês
Texto associado
Leia o texto para responder à questão.
Cell culture experiments are widely used in biomedical
research, regenerative medicine, and biotechnological
production. Due to restrictions on the use of laboratory animals
by animal protection laws and the strict implementation of the
3Rs (Replacement, Reduction, and Refinement) formulated
by William Russell and Rex Burch to improve the welfare
of animals, it can be expected that the general use of cell
lines will further increase during the next years to substitute
animal-based research. However, it should be noted that cell
culture experiments, if not properly conducted, are prone to
errors. Therefore, it is essential that cell culture studies are
performed with good cell culture practice (GCCP) to assure
the reproducibility of in vitro experimentation.
In particular, inter- and intra-specific cross-contamination
and cell misidentification, genetic drift, contamination with
bacteria, fungi, yeast, viruses, or chemicals, and lack of quality
control testing are widespread fatal cell culture problems that
contaminate the literature with false and irreproducible results.
Rough estimates suggest that the number of published papers
that used problematic cell lines is about 16.1%. Moreover, the
International Cell Line Authentication Committee (ICLAC) lists
576 misidentified or cross-contaminated cell lines in its latest
register released in June 2021.
(Weiskirchen S, Schröder SK, Buhl EM, Weiskirchen R. A Beginner’s
Guide to Cell Culture: Practical Advice for Preventing Needless Problems.
Cells. 2023 Feb 21;12(5):682. doi: 10.3390/cells12050682.
PMID: 36899818; PMCID: PMC10000895.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10000895/. Adaptado)
De acordo com o texto, é fundamental que experimentos
com culturas de células in vitro
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263845
Inglês
Texto associado
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The correction of genetic errors associated with
disease in animals suggests that gene editing has potential
applications in gene therapy for humans. Gene therapy is
the introduction of a normal gene into an individual’s genome
in order to repair a mutation that causes a genetic disease.
When a normal gene is inserted into a mutant nucleus, it most
likely will integrate into a chromosomal site different from the
defective allele. Although this may repair the mutation, a new
mutation may result if the normal gene integrates into another
functional gene. If the normal gene replaces the mutant allele,
there is a chance that the transformed cells will proliferate and
produce enough normal gene product for the entire body to be
restored to the undiseased phenotype.
(www.britannica.com/science/genetic-engineering/
Process-and-techniques. Adaptado)
The part of the text that indicates that an unwanted
problem may happen is:
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263846
Inglês
Texto associado
Leia o texto para responder à questão.
The correction of genetic errors associated with
disease in animals suggests that gene editing has potential
applications in gene therapy for humans. Gene therapy is
the introduction of a normal gene into an individual’s genome
in order to repair a mutation that causes a genetic disease.
When a normal gene is inserted into a mutant nucleus, it most
likely will integrate into a chromosomal site different from the
defective allele. Although this may repair the mutation, a new
mutation may result if the normal gene integrates into another
functional gene. If the normal gene replaces the mutant allele,
there is a chance that the transformed cells will proliferate and
produce enough normal gene product for the entire body to be
restored to the undiseased phenotype.
(www.britannica.com/science/genetic-engineering/
Process-and-techniques. Adaptado)
No trecho do texto – it most likely will integrate into a
chromosomal site different from the defective allele – o
termo em negrito indica
Ano: 2024
Banca:
VUNESP
Órgão:
UNICAMP
Prova:
VUNESP - 2024 - UNICAMP - Profissional de Pesquisa, Engenharia e Tecnologia |
Q3263847
Inglês
Texto associado
Leia o texto para responder à questão.
The correction of genetic errors associated with
disease in animals suggests that gene editing has potential
applications in gene therapy for humans. Gene therapy is
the introduction of a normal gene into an individual’s genome
in order to repair a mutation that causes a genetic disease.
When a normal gene is inserted into a mutant nucleus, it most
likely will integrate into a chromosomal site different from the
defective allele. Although this may repair the mutation, a new
mutation may result if the normal gene integrates into another
functional gene. If the normal gene replaces the mutant allele,
there is a chance that the transformed cells will proliferate and
produce enough normal gene product for the entire body to be
restored to the undiseased phenotype.
(www.britannica.com/science/genetic-engineering/
Process-and-techniques. Adaptado)
According to the text, gene therapy intends to
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