Questões de Vestibular UNIFESP 2014 para Vestibular
Foram encontradas 45 questões
Leia o texto para responder a questão.
Cumpridos dez anos de prisão por um crime que não pratiquei e do qual, entanto, nunca me defendi, morto para a vida e para os sonhos: nada podendo já esperar e coisa alguma desejando – eu venho fazer enfim a minha confissão: isto é, demonstrar a minha inocência.
Talvez não me acreditem. Decerto que não me acreditam. Mas pouco importa. O meu interesse hoje em gritar que não assassinei Ricardo de Loureiro é nulo. Não tenho família; não preciso que me reabilitem. Mesmo quem esteve dez anos preso, nunca se reabilita. A verdade simples é esta.
E àqueles que, lendo o que fica exposto, me perguntarem: “Mas por que não fez a sua confissão quando era tempo? Por que não demonstrou a sua inocência ao tribunal?”, a esses responderei: – A minha defesa era impossível. Ninguém me acreditaria. E fora inútil fazer-me passar por um embusteiro ou por um doido… Demais, devo confessar, após os acontecimentos em que me vira envolvido nessa época, ficara tão despedaçado que a prisão se me afigurava uma coisa sorridente. Era o esquecimento, a tranquilidade, o sono. Era um fim como qualquer outro – um termo para a minha vida devastada. Toda a minha ânsia foi pois de ver o processo terminado e começar cumprindo a minha sentença.
De resto, o meu processo foi rápido. Oh! o caso parecia bem claro… Eu nem negava nem confessava. Mas quem cala consente… E todas as simpatias estavam do meu lado.
O crime era, como devem ter dito os jornais do tempo, um “crime passional”. Cherchez la femme*. Depois, a vítima um poeta – um artista. A mulher romantizara-se desaparecendo. Eu era um herói, no fim de contas. E um herói com seus laivos de mistério, o que mais me aureolava. Por tudo isso, independentemente do belo discurso de defesa, o júri concedeu-me circunstâncias atenuantes. E a minha pena foi curta.
Ah! foi bem curta – sobretudo para mim… Esses dez
anos esvoaram-se-me como dez meses. É que, em realidade, as horas não podem mais ter ação sobre aqueles que viveram um instante que focou toda a sua vida.
Atingido o sofrimento máximo, nada já nos faz sofrer. Vibradas as sensações máximas, nada já nos fará oscilar.
Simplesmente, este momento culminante raras são as
criaturas que o vivem. As que o viveram ou são, como eu,
os mortos-vivos, ou – apenas – os desencantados que,
muita vez, acabam no suicídio.
* Cherchez la femme: Procurem a mulher.
(Mário de Sá-Carneiro. A confissão de Lúcio, 2011.)
Verifica-se a ocorrência de objeto direto pleonástico em:
Examine os enunciados:
“Vamos para a rua protestar.” (Texto 1) “Não será a adulteração de obras, para torná-las supostamente mais legíveis por ignorantes” (Texto 3)O termo “para”, em destaque nos enunciados, expressa,
respectivamente, sentido de
Examine a passagem do texto 2:
“e eventualmente se interessar por ler o Machadão no original. Agora, dar uma machadada em um moleque”
Os dois termos em destaque, derivados por sufixação, reportam a Machado de Assis. Tal recurso atribui aos substantivos, respectivamente, sentido de
A fala do condenado revela
Leia o trecho do conto “O mandarim”, de Eça de Queirós, para responder a questão.
Então começou a minha vida de milionário. Deixei bem depressa a casa de Madame Marques – que, desde que me sabia rico, me tratava todos os dias a arroz- -doce, e ela mesma me servia, com o seu vestido de seda dos domingos. Comprei, habitei o palacete amarelo, ao Loreto: as magnificências da minha instalação são bem conhecidas pelas gravuras indiscretas da Ilustração Francesa. Tornou-se famoso na Europa o meu leito, de um gosto exuberante e bárbaro, com a barra recoberta de lâminas de ouro lavrado e cortinados de um raro brocado negro onde ondeiam, bordados a pérolas, versos eróticos de Catulo; uma lâmpada, suspensa no interior, derrama ali a claridade láctea e amorosa de um luar de Verão.
[...]
Entretanto Lisboa rojava-se aos meus pés. O pátio do palacete estava constantemente invadido por uma turba: olhando-a enfastiado das janelas da galeria, eu via lá branquejar os peitilhos da Aristocracia, negrejar a sotaina do Clero, e luzir o suor da Plebe: todos vinham suplicar, de lábio abjeto, a honra do meu sorriso e uma participação no meu ouro. Às vezes consentia em receber algum velho de título histórico: – ele adiantava-se pela sala, quase roçando o tapete com os cabelos brancos, tartamudeando adulações; e imediatamente, espalmando sobre o peito a mão de fortes veias onde corria um sangue de três séculos, oferecia-me uma filha bem-amada para esposa ou para concubina.
Todos os cidadãos me traziam presentes como a um ídolo sobre o altar – uns odes votivas, outros o meu monograma bordado a cabelo, alguns chinelas ou boquilhas, cada um a sua consciência. Se o meu olhar amortecido fixava, por acaso, na rua, uma mulher – era logo ao outro dia uma carta em que a criatura, esposa ou prostituta, me ofertava a sua nudez, o seu amor, e todas as complacências da lascívia.
Os jornalistas esporeavam a imaginação para achar adjetivos dignos da minha grandeza; fui o sublime Sr. Teodoro, cheguei a ser o celeste Sr. Teodoro; então, desvairada, a Gazeta das Locais chamou-me o extraceleste Sr. Teodoro! Diante de mim nenhuma cabeça ficou jamais coberta – ou usasse a coroa ou o coco. Todos os dias me era oferecida uma presidência de Ministério ou uma direção de confraria. Recusei sempre, com nojo.
(Eça de Queirós. O mandarim, s/d.)
Ao descrever a sua vida de milionário, o narrador
Leia o trecho do conto “O mandarim”, de Eça de Queirós, para responder a questão.
Então começou a minha vida de milionário. Deixei bem depressa a casa de Madame Marques – que, desde que me sabia rico, me tratava todos os dias a arroz- -doce, e ela mesma me servia, com o seu vestido de seda dos domingos. Comprei, habitei o palacete amarelo, ao Loreto: as magnificências da minha instalação são bem conhecidas pelas gravuras indiscretas da Ilustração Francesa. Tornou-se famoso na Europa o meu leito, de um gosto exuberante e bárbaro, com a barra recoberta de lâminas de ouro lavrado e cortinados de um raro brocado negro onde ondeiam, bordados a pérolas, versos eróticos de Catulo; uma lâmpada, suspensa no interior, derrama ali a claridade láctea e amorosa de um luar de Verão.
[...]
Entretanto Lisboa rojava-se aos meus pés. O pátio do palacete estava constantemente invadido por uma turba: olhando-a enfastiado das janelas da galeria, eu via lá branquejar os peitilhos da Aristocracia, negrejar a sotaina do Clero, e luzir o suor da Plebe: todos vinham suplicar, de lábio abjeto, a honra do meu sorriso e uma participação no meu ouro. Às vezes consentia em receber algum velho de título histórico: – ele adiantava-se pela sala, quase roçando o tapete com os cabelos brancos, tartamudeando adulações; e imediatamente, espalmando sobre o peito a mão de fortes veias onde corria um sangue de três séculos, oferecia-me uma filha bem-amada para esposa ou para concubina.
Todos os cidadãos me traziam presentes como a um ídolo sobre o altar – uns odes votivas, outros o meu monograma bordado a cabelo, alguns chinelas ou boquilhas, cada um a sua consciência. Se o meu olhar amortecido fixava, por acaso, na rua, uma mulher – era logo ao outro dia uma carta em que a criatura, esposa ou prostituta, me ofertava a sua nudez, o seu amor, e todas as complacências da lascívia.
Os jornalistas esporeavam a imaginação para achar adjetivos dignos da minha grandeza; fui o sublime Sr. Teodoro, cheguei a ser o celeste Sr. Teodoro; então, desvairada, a Gazeta das Locais chamou-me o extraceleste Sr. Teodoro! Diante de mim nenhuma cabeça ficou jamais coberta – ou usasse a coroa ou o coco. Todos os dias me era oferecida uma presidência de Ministério ou uma direção de confraria. Recusei sempre, com nojo.
(Eça de Queirós. O mandarim, s/d.)
“Os jornalistas esporeavam a imaginação para achar adjetivos dignos da minha grandeza; fui o sublime Sr. Teodoro, cheguei a ser o celeste Sr. Teodoro; então, desvairada, a Gazeta das Locais chamou-me o extraceleste Sr. Teodoro!”
Nesta passagem do último parágrafo, identifica-se uma
Leia o trecho do conto “O mandarim”, de Eça de Queirós, para responder a questão.
Então começou a minha vida de milionário. Deixei bem depressa a casa de Madame Marques – que, desde que me sabia rico, me tratava todos os dias a arroz- -doce, e ela mesma me servia, com o seu vestido de seda dos domingos. Comprei, habitei o palacete amarelo, ao Loreto: as magnificências da minha instalação são bem conhecidas pelas gravuras indiscretas da Ilustração Francesa. Tornou-se famoso na Europa o meu leito, de um gosto exuberante e bárbaro, com a barra recoberta de lâminas de ouro lavrado e cortinados de um raro brocado negro onde ondeiam, bordados a pérolas, versos eróticos de Catulo; uma lâmpada, suspensa no interior, derrama ali a claridade láctea e amorosa de um luar de Verão.
[...]
Entretanto Lisboa rojava-se aos meus pés. O pátio do palacete estava constantemente invadido por uma turba: olhando-a enfastiado das janelas da galeria, eu via lá branquejar os peitilhos da Aristocracia, negrejar a sotaina do Clero, e luzir o suor da Plebe: todos vinham suplicar, de lábio abjeto, a honra do meu sorriso e uma participação no meu ouro. Às vezes consentia em receber algum velho de título histórico: – ele adiantava-se pela sala, quase roçando o tapete com os cabelos brancos, tartamudeando adulações; e imediatamente, espalmando sobre o peito a mão de fortes veias onde corria um sangue de três séculos, oferecia-me uma filha bem-amada para esposa ou para concubina.
Todos os cidadãos me traziam presentes como a um ídolo sobre o altar – uns odes votivas, outros o meu monograma bordado a cabelo, alguns chinelas ou boquilhas, cada um a sua consciência. Se o meu olhar amortecido fixava, por acaso, na rua, uma mulher – era logo ao outro dia uma carta em que a criatura, esposa ou prostituta, me ofertava a sua nudez, o seu amor, e todas as complacências da lascívia.
Os jornalistas esporeavam a imaginação para achar adjetivos dignos da minha grandeza; fui o sublime Sr. Teodoro, cheguei a ser o celeste Sr. Teodoro; então, desvairada, a Gazeta das Locais chamou-me o extraceleste Sr. Teodoro! Diante de mim nenhuma cabeça ficou jamais coberta – ou usasse a coroa ou o coco. Todos os dias me era oferecida uma presidência de Ministério ou uma direção de confraria. Recusei sempre, com nojo.
(Eça de Queirós. O mandarim, s/d.)
Leia o soneto de Cruz e Sousa.
SilênciosLargos Silêncios interpretativos,
Adoçados por funda nostalgia,
Balada de consolo e simpatia
Que os sentimentos meus torna cativos;
Harmonia de doces lenitivos,
Sombra, segredo, lágrima, harmonia
Da alma serena, da alma fugidia
Nos seus vagos espasmos sugestivos.
Ó Silêncios! ó cândidos desmaios,
Vácuos fecundos de celestes raios
De sonhos, no mais límpido cortejo...
Eu vos sinto os mistérios insondáveis
Como de estranhos anjos inefáveis
O glorioso esplendor de um grande beijo!
(Cruz e Sousa. Broquéis, Faróis, Últimos Sonetos, 2008.)
Examine o quadrinho para responder a questão.
The Joy of Tech by Nitrozac & Snaggy
Examine o quadrinho para responder a questão.
The Joy of Tech by Nitrozac & Snaggy
Leia o texto para responder a questão.
Healthy choices
How do we reduce waistlines in a country where we traditionally do not like telling individuals what to do?
By Telegraph View
22 Aug 2014
Duncan Selbie, the Chief Executive of Public Health
England, suggests that parents feed their children
from smaller plates. Photo: Alamy
Every new piece of information about Britain’s weight problem makes for ever more depressing reading. Duncan Selbie, the Chief Executive of Public Health England, today tells us that by 2034 some six million Britons will suffer from diabetes. Of course, many people develop diabetes through no fault of their own. But Mr Selbie’s research concludes that if the levels of obesity returned to their 1994 levels, 1.7 million fewer people would suffer from the condition.
Given that fighting diabetes already drains the National Health Service (NHS) by more than £1.5 million, or 10 per cent of its budget for England, the impact upon the Treasury in 20 years’ time from unhealthy lifestyles could be catastrophic. Bad health not only impacts on the individual but also on the rest of the community.
Diagnosis of the challenge is straightforward. The tougher question is what to do about reducing waistlines in a country where we traditionally do not like telling individuals what to do.
It is interesting to note that Mr Selbie does not ascribe to the Big Brother approach of ceaseless legislation and nannying. Rather, he is keen to promote choices – making the case passionately that people should be encouraged to embrace good health. One of his suggestions is that parents feed their children from smaller plates. That way the child can clear his or her plate, as ordered, without actually consuming too much. Like all good ideas, this is rooted in common sense.
(www.telegraph.co.uk. Adaptado.)
Leia o texto para responder a questão.
Healthy choices
How do we reduce waistlines in a country where we traditionally do not like telling individuals what to do?
By Telegraph View
22 Aug 2014
Duncan Selbie, the Chief Executive of Public Health
England, suggests that parents feed their children
from smaller plates. Photo: Alamy
Every new piece of information about Britain’s weight problem makes for ever more depressing reading. Duncan Selbie, the Chief Executive of Public Health England, today tells us that by 2034 some six million Britons will suffer from diabetes. Of course, many people develop diabetes through no fault of their own. But Mr Selbie’s research concludes that if the levels of obesity returned to their 1994 levels, 1.7 million fewer people would suffer from the condition.
Given that fighting diabetes already drains the National Health Service (NHS) by more than £1.5 million, or 10 per cent of its budget for England, the impact upon the Treasury in 20 years’ time from unhealthy lifestyles could be catastrophic. Bad health not only impacts on the individual but also on the rest of the community.
Diagnosis of the challenge is straightforward. The tougher question is what to do about reducing waistlines in a country where we traditionally do not like telling individuals what to do.
It is interesting to note that Mr Selbie does not ascribe to the Big Brother approach of ceaseless legislation and nannying. Rather, he is keen to promote choices – making the case passionately that people should be encouraged to embrace good health. One of his suggestions is that parents feed their children from smaller plates. That way the child can clear his or her plate, as ordered, without actually consuming too much. Like all good ideas, this is rooted in common sense.
(www.telegraph.co.uk. Adaptado.)
Leia o texto para responder a questão.
Healthy choices
How do we reduce waistlines in a country where we traditionally do not like telling individuals what to do?
By Telegraph View
22 Aug 2014
Duncan Selbie, the Chief Executive of Public Health
England, suggests that parents feed their children
from smaller plates. Photo: Alamy
Every new piece of information about Britain’s weight problem makes for ever more depressing reading. Duncan Selbie, the Chief Executive of Public Health England, today tells us that by 2034 some six million Britons will suffer from diabetes. Of course, many people develop diabetes through no fault of their own. But Mr Selbie’s research concludes that if the levels of obesity returned to their 1994 levels, 1.7 million fewer people would suffer from the condition.
Given that fighting diabetes already drains the National Health Service (NHS) by more than £1.5 million, or 10 per cent of its budget for England, the impact upon the Treasury in 20 years’ time from unhealthy lifestyles could be catastrophic. Bad health not only impacts on the individual but also on the rest of the community.
Diagnosis of the challenge is straightforward. The tougher question is what to do about reducing waistlines in a country where we traditionally do not like telling individuals what to do.
It is interesting to note that Mr Selbie does not ascribe to the Big Brother approach of ceaseless legislation and nannying. Rather, he is keen to promote choices – making the case passionately that people should be encouraged to embrace good health. One of his suggestions is that parents feed their children from smaller plates. That way the child can clear his or her plate, as ordered, without actually consuming too much. Like all good ideas, this is rooted in common sense.
(www.telegraph.co.uk. Adaptado.)
Leia o texto para responder a questão.
Healthy choices
How do we reduce waistlines in a country where we traditionally do not like telling individuals what to do?
By Telegraph View
22 Aug 2014
Duncan Selbie, the Chief Executive of Public Health
England, suggests that parents feed their children
from smaller plates. Photo: Alamy
Every new piece of information about Britain’s weight problem makes for ever more depressing reading. Duncan Selbie, the Chief Executive of Public Health England, today tells us that by 2034 some six million Britons will suffer from diabetes. Of course, many people develop diabetes through no fault of their own. But Mr Selbie’s research concludes that if the levels of obesity returned to their 1994 levels, 1.7 million fewer people would suffer from the condition.
Given that fighting diabetes already drains the National Health Service (NHS) by more than £1.5 million, or 10 per cent of its budget for England, the impact upon the Treasury in 20 years’ time from unhealthy lifestyles could be catastrophic. Bad health not only impacts on the individual but also on the rest of the community.
Diagnosis of the challenge is straightforward. The tougher question is what to do about reducing waistlines in a country where we traditionally do not like telling individuals what to do.
It is interesting to note that Mr Selbie does not ascribe to the Big Brother approach of ceaseless legislation and nannying. Rather, he is keen to promote choices – making the case passionately that people should be encouraged to embrace good health. One of his suggestions is that parents feed their children from smaller plates. That way the child can clear his or her plate, as ordered, without actually consuming too much. Like all good ideas, this is rooted in common sense.
(www.telegraph.co.uk. Adaptado.)
Leia o texto para responder a questão.
Healthy choices
How do we reduce waistlines in a country where we traditionally do not like telling individuals what to do?
By Telegraph View
22 Aug 2014
Duncan Selbie, the Chief Executive of Public Health
England, suggests that parents feed their children
from smaller plates. Photo: Alamy
Every new piece of information about Britain’s weight problem makes for ever more depressing reading. Duncan Selbie, the Chief Executive of Public Health England, today tells us that by 2034 some six million Britons will suffer from diabetes. Of course, many people develop diabetes through no fault of their own. But Mr Selbie’s research concludes that if the levels of obesity returned to their 1994 levels, 1.7 million fewer people would suffer from the condition.
Given that fighting diabetes already drains the National Health Service (NHS) by more than £1.5 million, or 10 per cent of its budget for England, the impact upon the Treasury in 20 years’ time from unhealthy lifestyles could be catastrophic. Bad health not only impacts on the individual but also on the rest of the community.
Diagnosis of the challenge is straightforward. The tougher question is what to do about reducing waistlines in a country where we traditionally do not like telling individuals what to do.
It is interesting to note that Mr Selbie does not ascribe to the Big Brother approach of ceaseless legislation and nannying. Rather, he is keen to promote choices – making the case passionately that people should be encouraged to embrace good health. One of his suggestions is that parents feed their children from smaller plates. That way the child can clear his or her plate, as ordered, without actually consuming too much. Like all good ideas, this is rooted in common sense.
(www.telegraph.co.uk. Adaptado.)
Leia o texto para responder a questão.
Healthy choices
How do we reduce waistlines in a country where we traditionally do not like telling individuals what to do?
By Telegraph View
22 Aug 2014
Duncan Selbie, the Chief Executive of Public Health
England, suggests that parents feed their children
from smaller plates. Photo: Alamy
Every new piece of information about Britain’s weight problem makes for ever more depressing reading. Duncan Selbie, the Chief Executive of Public Health England, today tells us that by 2034 some six million Britons will suffer from diabetes. Of course, many people develop diabetes through no fault of their own. But Mr Selbie’s research concludes that if the levels of obesity returned to their 1994 levels, 1.7 million fewer people would suffer from the condition.
Given that fighting diabetes already drains the National Health Service (NHS) by more than £1.5 million, or 10 per cent of its budget for England, the impact upon the Treasury in 20 years’ time from unhealthy lifestyles could be catastrophic. Bad health not only impacts on the individual but also on the rest of the community.
Diagnosis of the challenge is straightforward. The tougher question is what to do about reducing waistlines in a country where we traditionally do not like telling individuals what to do.
It is interesting to note that Mr Selbie does not ascribe to the Big Brother approach of ceaseless legislation and nannying. Rather, he is keen to promote choices – making the case passionately that people should be encouraged to embrace good health. One of his suggestions is that parents feed their children from smaller plates. That way the child can clear his or her plate, as ordered, without actually consuming too much. Like all good ideas, this is rooted in common sense.
(www.telegraph.co.uk. Adaptado.)
Leia o texto para responder a questão.
The Rise of Antibiotic Resistance
By The Editorial Board
May 10, 2014
The World Health Organization has surveyed the growth of antibiotic-resistant germs around the world – the first such survey it has ever conducted – and come up with disturbing findings. In a report issued late last month, the organization found that antimicrobial resistance in bacteria (the main focus of the report), fungi, viruses and parasites is an increasingly serious threat in every part of the world. “A problem so serious that it threatens the achievements of modern medicine,” the organization said. “A post-antibiotic era, in which common infections and minor injuries can kill, far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century.”
The growth of antibiotic-resistant pathogens means that in ever more cases, standard treatments no longer work, infections are harder or impossible to control, the risk of spreading infections to others is increased, and illnesses and hospital stays are prolonged. All of these drive up the costs of illnesses and the risk of death. The survey sought to determine the scope of the problem by asking countries to submit their most recent surveillance data (114 did so). Unfortunately, the data was glaringly incomplete because few countries track and monitor antibiotic resistance comprehensively, and there is no standard methodology for doing so.
Still, it is clear that major resistance problems have already developed, both for antibiotics that are used routinely and for those deemed “last resort” treatments to cure people when all else has failed. Carbapenem antibiotics, a class of drugs used as a last resort to treat life-threatening infections caused by a common intestinal bacterium, have failed to work in more than half the people treated in some countries. The bacterium is a major cause of hospital-acquired infections such as pneumonia, bloodstream infections, and infections in newborns and intensive-care patients. Similarly, the failure of a last-resort treatment for gonorrhoea has been confirmed in 10 countries, including many with advanced health care systems, such as Australia, Canada, France, Sweden and Britain. And resistance to a class of antibiotics that is routinely used to treat urinary tract infections caused by E. coli is widespread; in some countries the drugs are now ineffective in more than half of the patients treated. This sobering report is intended to kick-start a global campaign to develop tools and standards to track drug resistance, measure its health and economic impact, and design solutions.
The most urgent need is to minimize the overuse of antibiotics in medicine and agriculture, which accelerates the development of resistant strains. In the United States, the Food and Drug Administration (FDA) has issued voluntary guidelines calling on drug companies, animal producers and veterinarians to stop indiscriminately using antibiotics that are important for treating humans on livestock; the drug companies have said they will comply. But the agency, shortsightedly, has appealed a court order requiring it to ban the use of penicillin and two forms of tetracycline by animal producers to promote growth unless they provide proof that it will not promote drug-resistant microbes.
The pharmaceutical industry needs to be encouraged to develop new antibiotics to supplement those that are losing their effectiveness. The Royal Pharmaceutical Society, which represents pharmacists in Britain, called this month for stronger financial incentives. It said that no new class of antibiotics has been discovered since 1987, largely because the financial returns for finding new classes of antibiotics are too low. Unlike lucrative drugs to treat chronic diseases like cancer and cardiovascular ailments, antibiotics are typically taken for a short period of time, and any new drug is apt to be used sparingly and held in reserve to treat patients resistant to existing drugs. Antibiotics have transformed medicine and saved countless lives over the past seven decades. Now, rampant overuse and the lack of new drugs in the pipeline threaten to undermine their effectiveness.
(www.nytimes.com. Adaptado.)
Leia o texto para responder a questão.
The Rise of Antibiotic Resistance
By The Editorial Board
May 10, 2014
The World Health Organization has surveyed the growth of antibiotic-resistant germs around the world – the first such survey it has ever conducted – and come up with disturbing findings. In a report issued late last month, the organization found that antimicrobial resistance in bacteria (the main focus of the report), fungi, viruses and parasites is an increasingly serious threat in every part of the world. “A problem so serious that it threatens the achievements of modern medicine,” the organization said. “A post-antibiotic era, in which common infections and minor injuries can kill, far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century.”
The growth of antibiotic-resistant pathogens means that in ever more cases, standard treatments no longer work, infections are harder or impossible to control, the risk of spreading infections to others is increased, and illnesses and hospital stays are prolonged. All of these drive up the costs of illnesses and the risk of death. The survey sought to determine the scope of the problem by asking countries to submit their most recent surveillance data (114 did so). Unfortunately, the data was glaringly incomplete because few countries track and monitor antibiotic resistance comprehensively, and there is no standard methodology for doing so.
Still, it is clear that major resistance problems have already developed, both for antibiotics that are used routinely and for those deemed “last resort” treatments to cure people when all else has failed. Carbapenem antibiotics, a class of drugs used as a last resort to treat life-threatening infections caused by a common intestinal bacterium, have failed to work in more than half the people treated in some countries. The bacterium is a major cause of hospital-acquired infections such as pneumonia, bloodstream infections, and infections in newborns and intensive-care patients. Similarly, the failure of a last-resort treatment for gonorrhoea has been confirmed in 10 countries, including many with advanced health care systems, such as Australia, Canada, France, Sweden and Britain. And resistance to a class of antibiotics that is routinely used to treat urinary tract infections caused by E. coli is widespread; in some countries the drugs are now ineffective in more than half of the patients treated. This sobering report is intended to kick-start a global campaign to develop tools and standards to track drug resistance, measure its health and economic impact, and design solutions.
The most urgent need is to minimize the overuse of antibiotics in medicine and agriculture, which accelerates the development of resistant strains. In the United States, the Food and Drug Administration (FDA) has issued voluntary guidelines calling on drug companies, animal producers and veterinarians to stop indiscriminately using antibiotics that are important for treating humans on livestock; the drug companies have said they will comply. But the agency, shortsightedly, has appealed a court order requiring it to ban the use of penicillin and two forms of tetracycline by animal producers to promote growth unless they provide proof that it will not promote drug-resistant microbes.
The pharmaceutical industry needs to be encouraged to develop new antibiotics to supplement those that are losing their effectiveness. The Royal Pharmaceutical Society, which represents pharmacists in Britain, called this month for stronger financial incentives. It said that no new class of antibiotics has been discovered since 1987, largely because the financial returns for finding new classes of antibiotics are too low. Unlike lucrative drugs to treat chronic diseases like cancer and cardiovascular ailments, antibiotics are typically taken for a short period of time, and any new drug is apt to be used sparingly and held in reserve to treat patients resistant to existing drugs. Antibiotics have transformed medicine and saved countless lives over the past seven decades. Now, rampant overuse and the lack of new drugs in the pipeline threaten to undermine their effectiveness.
(www.nytimes.com. Adaptado.)
Conheça nossos planos